The economic value of targeting aging

Link: https://www.nature.com/articles/s43587-021-00080-0?fbclid=IwAR30GYDrmx1ck_1CkFvkoJUR4EttL4OxkNOgD9ZYft_jvqYa-inOhhthZao

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Developments in life expectancy and the growing emphasis on biological and ‘healthy’ aging raise a number of important questions for health scientists and economists alike. Is it preferable to make lives healthier by compressing morbidity, or longer by extending life? What are the gains from targeting aging itself compared to efforts to eradicate specific diseases? Here we analyze existing data to evaluate the economic value of increases in life expectancy, improvements in health and treatments that target aging. We show that a compression of morbidity that improves health is more valuable than further increases in life expectancy, and that targeting aging offers potentially larger economic gains than eradicating individual diseases. We show that a slowdown in aging that increases life expectancy by 1 year is worth US$38 trillion, and by 10 years, US$367 trillion. Ultimately, the more progress that is made in improving how we age, the greater the value of further improvements.

Author(s): Andrew J. Scott, Martin Ellison, David A. Sinclair

Publication Date: 5 July 2021

Publication Site: Nature Aging

Mortality with Meep: U.S. Life Expectancy Fell 2.4% in 2020, and Death Rates Increased 16.1%

Link: https://marypatcampbell.substack.com/p/mortality-with-meep-us-life-expectancy

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The Spanish flu pandemic gives us the demonstration of what happens when there is a short-term large increase in mortality.

Using Social Security records of period life expectancy, there was a huge drop in life expectancy in 1918…. and then a huge increase in 1919. But going from 1917 to 1919 wasn’t really that big of a difference.

The period life expectancy drop was 12% for females, 13% for males in 1918.

Then there was an increase of 15% for females, 20% for males in 1919. The Spanish flu hit the U.S. hard in 1918, and let up in 1919.

If you compare 1919 against 1917, the life expectancy from birth increase was 1% for females, and 4% increase for males — male life expectancy was down in 1917 compared to 1916, probably related to World War I.

Author(s): Mary Pat Campbell

Publication Date: 29 June 2021

Publication Site: STUMP at substack

Will Your Life Be Shortened By The Pandemic?

Link: https://www.forbes.com/sites/stevevernon/2021/06/25/will-your-life-be-shortened-by-the-pandemic/?sh=177b1c0f1952

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Now, because the pandemic produced higher death rates in 2020 compared to prior years, a period life expectancy calculated for 2020 produced lower life expectancies compared to period life expectancies calculated for prior years. That’s because it’s assumed that the elevated death rates we experienced in 2020 would apply to all future years. But if the death rates decline in 2021, then any period life expectancies calculated for 2021 would most likely be higher. And that’s certainly the hope, given that a large portion of the population has received a vaccine, which is already resulting in a dramatic decline in new infections and hospitalizations. 

If you’ve survived the pandemic with your health relatively intact and if you’ve also received the vaccine, then it’s highly likely the virus won’t shorten your lifespan. Of course, new deadly variants or future deadly viruses could change that conclusion, but for now, the outlook is positive.

“Cohort life expectancies” on the other hand, are calculated for a group of people reflecting their characteristics and the experience they might expect over their lifetimes. These life expectancies are calculated in the same way as period life expectancies, except that the death rates used to estimate someone’s remaining future years are modified to reflect anticipated future changes in death rates. If you want to estimate your own remaining lifespan, a cohort life expectancy is often most appropriate.

Author(s): Steve Vernon

Publication Date: 25 June 2021

Publication Site: Forbes

Life expectancy in U.S. dropped by almost two years between 2018 and 2020

Link: https://www.benefitspro.com/2021/06/28/life-expectancy-in-u-s-dropped-by-almost-two-years-between-2018-and-2020/

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Life expectancy in the United States between 2018 and 2020 decreased by 1.87 years (to 76.87 years), which is 8.5 times the average decrease in other high-income nations. What’s more, decreases in life expectancy among Hispanic and non-Hispanic Black people were about two to three times greater than in the non-Hispanic White population, reversing years of progress in reducing racial and ethnic disparities. The life expectancy of Black men (67.73 years) is the lowest since 1998.

Those are key findings of a study conducted by researchers at the Virginia Commonwealth University School of Medicine, the University of Colorado Population Center and the Urban Institute in Washington, D.C., and published in The BMJ — a peer-reviewed medical trade journal of the British Medical Association.

Author(s): Michael Popke

Publication Date: 28 June 2021

Publication Site: Benefits Pro

Effect of the covid-19 pandemic in 2020 on life expectancy across populations in the USA and other high income countries: simulations of provisional mortality data

Link: https://www.bmj.com/content/373/bmj.n1343

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Results Between 2010 and 2018, the gap in life expectancy between the US and the peer country average increased from 1.88 years (78.66 v 80.54 years, respectively) to 3.05 years (78.74 v 81.78 years). Between 2018 and 2020, life expectancy in the US decreased by 1.87 years (to 76.87 years), 8.5 times the average decrease in peer countries (0.22 years), widening the gap to 4.69 years. Life expectancy in the US decreased disproportionately among racial and ethnic minority groups between 2018 and 2020, declining by 3.88, 3.25, and 1.36 years in Hispanic, non-Hispanic Black, and non-Hispanic White populations, respectively. In Hispanic and non-Hispanic Black populations, reductions in life expectancy were 18 and 15 times the average in peer countries, respectively. Progress since 2010 in reducing the gap in life expectancy in the US between Black and White people was erased in 2018-20; life expectancy in Black men reached its lowest level since 1998 (67.73 years), and the longstanding Hispanic life expectancy advantage almost disappeared.

Conclusions The US had a much larger decrease in life expectancy between 2018 and 2020 than other high income nations, with pronounced losses among the Hispanic and non-Hispanic Black populations. A longstanding and widening US health disadvantage, high death rates in 2020, and continued inequitable effects on racial and ethnic minority groups are likely the products of longstanding policy choices and systemic racism.

BMJ 2021; 373 doi: https://doi.org/10.1136/bmj.n1343 (Published 24 June 2021)Cite this as: BMJ 2021;373:n1343

Author(s): Steven H Woolf, Ryan K Masters, Laudan Y Aron

Publication Date: 24 June 2021

Publication Site: bmj

Black and Hispanic Americans Suffer Most in Biggest US Decline in Life Expectancy Since WWII

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Indeed, new research published Wednesday in the BMJ shows just how wide that gap has grown. Life expectancy across the country plummeted by nearly two years from 2018 to 2020, the largest decline since 1943, when American troops were dying in World War II, according to the study. But while white Americans lost 1.36 years, Black Americans lost 3.25 years and Hispanic Americans lost 3.88 years. Given that life expectancy typically varies only by a month or two from year to year, losses of this magnitude are “pretty catastrophic,” said Dr. Steven Woolf, a professor at Virginia Commonwealth University and lead author of the study.

Over the two years included in the study, the average loss of life expectancy in the U.S. was nearly nine times greater than the average in 16 other developed nations, whose residents can now expect to live 4.7 years longer than Americans. Compared with their peers in other countries, Americans died not only in greater numbers but at younger ages during this period.

The U.S. mortality rate spiked by nearly 23% in 2020, when there were roughly 522,000 more deaths than normally would be expected. Not all of these deaths were directly attributable to covid-19. Fatal heart attacks and strokes both increased in 2020, at least partly fueled by delayed treatment or lack of access to medical care, Woolf said. More than 40% of Americans put off treatment during the early months of the pandemic, when hospitals were stretched thin and going into a medical facility seemed risky. Without prompt medical attention, heart attacks can cause congestive heart failure; delaying treatment of strokes raises the risk of long-term disability.

Author(s): Liz Szabo

Publication Date: 24 June 2021

Publication Site: Kaiser Health News

The State of Health for Blacks in Chicago

Link: https://www.chicago.gov/content/dam/city/depts/cdph/CDPH/Healthy%20Chicago/CDPH_BlackHealth7c_DIGITAL.pdf

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Leading causes of death among Blacks differ by sex. Among Black males, homicide and accidents (such as drug overdoses and motor vehicle accidents) combined make up almost as many deaths as deaths due to cancer. Stroke and kidney disease cause higher proportion of deaths among Black females compared to males and non-Blacks.

Author(s): Chicago Department of Public Health

Publication Date: June 2021

Publication Site: City of Chicago

Populists May Kill Chile’s Pension Success

Link: https://www.wsj.com/articles/populists-may-kill-chiles-pension-success-11622670275

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Populist politicians are destroying Chile’s revolutionary pension system. In 1981 Chile became the first country to privatize social security, ending the pay-as-you-go system that had been in place since 1924 and had collapsed. Now Chile’s left wants to resurrect it.

The state-run pension system was plagued by corruption and rent-seeking since its earliest days. Among the 11,395 laws passed by the Chilean Congress between 1926 and 1963, 10,532 granted pension privileges to special-interest groups, many of them politically connected. In 1968, Chilean President Eduardo Frei, a center-left Christian Democrat, described the cronyism that plagued social security as an “absurd monstrosity” that the government couldn’t afford.

Pension privatization reversed this perverse dynamic. Instead of taxing active workers to pay pensioners through the bureaucracy, the new system, created by former Labor Minister Jose Pinera, established that 10% of the employee’s salary is transferred automatically to an account under his name at one of the Administradoras de Fondos de Pensiones, or AFP. These private pension funds compete to attract workers and invest their pensions for a fee.

This has restored the link between contributions and pension benefits by making workers responsible for saving the funds that will support them once they retire. This novel system also limited corruption and rent-seeking, and Chilean taxpayers are no longer on the hook for pension deficits, which in 1981 represented 3% of gross domestic product.

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Longer life expectancy is also a problem. When the AFP system was created, men retired at 65 with an average life expectancy around 67. Women retired at the age of 60 with a life expectancy around 74. Today, the retirement ages are unchanged but life expectancy has increased to 77 for men and 83 for women. This means more years of retirement have to be funded by the same years of saving.

Author(s): Axel Kaiser

Publication Date: 2 June 2021

Publication Site: WSJ

Over the past century, African-American life expectancy and education levels have soared

Link: https://www.economist.com/graphic-detail/2021/05/20/over-the-past-century-african-american-life-expectancy-and-education-levels-have-soared

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AT THE turn of the twentieth century, a newborn white American could expect to live for around 48 years. That was 15 years longer than a newborn African-American could expect. Improvements in hygiene, medicine and other public-health measures led those numbers to rise dramatically. By mid-century, life expectancy for African-Americans had nearly doubled, to 61 years, while for white Americans it rose to 69. By 2017 the gap had narrowed further, to three and a half years: 75.3 for African-Americans, 78.8 for whites. But Hispanic Americans outlive them both, to an average of 81.8 years. In other words, both races have progressed significantly, but gaps remain. This same pattern exists across a number of metrics.

The most disturbing aspect of this pattern is not just the enduring gap in outcomes between black and white Americans, though it has narrowed markedly. It is that, as the work of Anne Case and Angus Deaton, both economists at Princeton, has shown, life expectancy fell for all demographic groups of Americans between 2014 and 2017 for the first time since 1993. The rise in mortality rates has been especially stark for whites without college degrees, owing to what they call “deaths of despair”: drug overdoses, suicide and diseases caused by heavy drinking.

Publication Date: 20 May 2021

Publication Site: The Economist

Quantifying impacts of the COVID-19 pandemic through life expectancy losses: a population-level study of 29 countries

Link: https://www.medrxiv.org/content/10.1101/2021.03.02.21252772v4

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Variations in the age patterns and magnitudes of excess deaths, as well as differences in population sizes and age structures make cross-national comparisons of the cumulative mortality impacts of the COVID-19 pandemic challenging. Life expectancy is a widely-used indicator that provides a clear and cross-nationally comparable picture of the population-level impacts of the pandemic on mortality. Life tables by sex were calculated for 29 countries, including most European countries, Chile and the USA for 2015-2020. Life expectancy at birth and at age 60 for 2020 were contextualised against recent trends between 2015-19. Using decomposition techniques we examined which specific age groups contributed to reductions in life expectancy in 2020 and to what extent reductions were attributable to official COVID-19 deaths. Life expectancy at birth declined from 2019 to 2020 in 27 out of 29 countries. Males in the USA and Bulgaria experienced the largest losses in life expectancy at birth during 2020 (2.1 and 1.6 years respectively), but reductions of more than an entire year were documented in eleven countries for males, and eight among females. Reductions were mostly attributable to increased mortality above age 60 and to official COVID-19 deaths. The COVID-19 pandemic triggered significant mortality increases in 2020 of a magnitude not witnessed since WW-II in Western Europe or the breakup of the Soviet Union in Eastern Europe. Females from 15 countries and males from 10 ended up with lower life expectancy at birth in 2020 than in 2015.

Author(s): José Manuel Aburto, Jonas Schöley, Ilya Kashnitsky, Luyin Zhang, Charles Rahal, Trifon I. Missov Melinda C. Mills, Jennifer B. Dowd, Ridhi Kashyap

Publication Date: 6 April 2021

Publication Site: medRxiv

Death rates at specific life stages mold the sex gap in life expectancy

Link: https://www.pnas.org/content/118/20/e2010588118

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Female life expectancy exceeds male life expectancy. Males at ages 15 to 40 die at rates that are often three times female levels, but this excess mortality is not the main cause of the life expectancy gap. Few deaths occur at younger adult ages compared with mortality after age 60 or, historically, among newborns. Our demographic analysis shows that, up through the early decades of the 20th century, the life expectancy gap largely resulted from excess deaths of infant boys. Afterward, higher mortality among men 60+ became crucial. The higher mortality of males at ages 15 to 40 has played a modest role.

Author(s): Virginia Zarulli, Ilya Kashnitsky, James W. Vaupel

Supplementary online material: https://www.pnas.org/content/pnas/suppl/2021/05/06/2010588118.DCSupplemental/pnas.2010588118.sapp.pdf

Github: https://github.com/CPop-SDU/sex-gap-e0-pnas

Publication Date: 18 May 2021

Publication Site: PNAS

The older you get, the higher your life expectancy

Link: https://blog.datawrapper.de/the-older-you-get-the-higher-your-life-expectancy/

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But here’s what I only started to understand last week (and I was kind of mind-blown by that, so I’m thrilled to share it with you): Our life expectancy increases with every minute we live. When I turned 30, my life expectancy got up to 90.37 years. Once I turn 80, it’ll be 93.76 years.

Author(s): Lisa Charlotte Rost

Publication Date: 25 March 2021

Publication Site: Datawrapper