Successful 10-second one-legged stance performance predicts survival in middle-aged and older individuals

Link: https://bjsm.bmj.com/content/56/17/975

Abstract:

Objectives Balance quickly diminishes after the mid-50s increasing the risk for falls and other adverse health outcomes. Our aim was to assess whether the ability to complete a 10- s one-legged stance (10-second OLS) is associated with all-cause mortality and whether it adds relevant prognostic information beyond ordinary demographic, anthropometric and clinical data.

Methods Anthropometric, clinical and vital status and 10-s OLS data were assessed in 1702 individuals (68% men) aged 51–75 years between 2008 and 2020. Log-rank and Cox modelling were used to compare survival curves and risk of death according to ability (YES) or inability (NO) to complete the 10-s OLS test.

Results Overall, 20.4% of the individuals were classified as NO. During a median follow-up of 7 years, 7.2% died, with 4.6% (YES) and 17.5% (NO) on the 10-s OLS. Survival curves were worse for NO 10-s OLS (log-rank test=85.6; p<0.001). In an adjusted model incorporating age, sex, body mass index and comorbidities, the HR of all-cause mortality was higher (1.84 (95% CI: 1.23 to 2.78) (p<0.001)) for NO individuals. Adding 10-s OLS to a model containing established risk factors was associated with significantly improved mortality risk prediction as measured by differences in −2 log likelihood and integrated discrimination improvement.

Conclusions Within the limitations of uncontrolled variables such as recent history of falls and physical activity, the ability to successfully complete the 10-s OLS is independently associated with all-cause mortality and adds relevant prognostic information beyond age, sex and several other anthropometric and clinical variables. There is potential benefit to including the 10-s OLS as part of routine physical examination in middle-aged and older adults.

Author(s): Araujo CG, de Souza e Silva CG, Laukkanen JA, et al

Publication Date:

Publication history
Accepted April 19, 2022
First published June 21, 2022.
Online issue publication
August 24, 2022

Publication Site: British Journal of Sports Medicine

Citation:

Araujo CG, de Souza e Silva CG, Laukkanen JA, et al

Successful 10-second one-legged stance performance predicts survival in middle-aged and older individuals

British Journal of Sports Medicine 2022;56:975-980.

doi: http://dx.doi.org/10.1136/bjsports-2021-105360

Naked mole rats defy the biological law of aging

Link: https://www.science.org/content/article/naked-mole-rats-defy-biological-law-aging

Excerpt:

The first study to analyze the life histories of thousands of naked mole rats has found that their risk of death doesn’t go up as they grow older, as it does for every other known mammalian species. Although some scientists caution against any sweeping conclusions, many say the new data are important and striking.

“This is remarkably low mortality,” says Caleb Finch, a biogerontologist at the University of Southern California in Los Angeles who was not involved in the new study. “At advanced ages, their mortality rate remains lower than any other mammal that has been documented.”

Scientists have long noted that naked mole rats—burrowing rodents with wrinkled, pink skin and large protruding teeth that live in large, subterranean colonies—show few signs of aging and far surpass the life span expected of a rodent this size. Mice in captivity live at most 4 years; based on their size, naked mole rats would not be expected to live past 6 years. Instead, some live beyond 30 years, and even at that age breeding females stay fertile.

Author(s): KAI KUPFERSCHMIDT

Publication Date: 26 JAN 2018

Publication Site: Science